Metabolites, Free Full-Text
Alcohol polyethoxylates (AEOs), such as cetyl alcohol ethoxylates (CetAEOs), are high-production-volume surfactants used in laundry detergents, hard-surface cleaners, pesticide formulations, textile production, oils, paints, and other products. AEOs have been suggested as lower toxicity replacements for alkylphenol polyethoxylates (APEOs), such as the nonylphenol and octylphenol polyethoxylates. We previously demonstrated that nonylphenol polyethoxylates induced triglyceride accumulation in several in vitro adipogenesis models and promoted adiposity and increased body weights in developmentally exposed zebrafish. We also demonstrated that diverse APEOs and AEOs were able to increase triglyceride accumulation and/or pre-adipocyte proliferation in a murine pre-adipocyte model. As such, the goals of this study were to assess the potential of CetAEOs to promote adiposity and alter growth and/or development (toxicity, length, weight, behavior, energy expenditure) of developmentally exposed zebrafish (Danio rerio). We also sought to expand our understanding of ethoxylate chain-length dependent effects through interrogation of varying chain-length CetAEOs. We demonstrated consistent adipogenic effects in two separate human bone-marrow-derived mesenchymal stem cell models as well as murine pre-adipocytes. Immediately following chemical exposures in zebrafish, we reported disrupted neurodevelopment and aberrant behavior in light/dark activity testing, with medium chain-length CetAEO-exposed fish exhibiting hyperactivity across both light and dark phases. By day 30, we demonstrated that cetyl alcohol and CetAEOs disrupted adipose deposition in developmentally exposed zebrafish, despite no apparent impacts on standard length or gross body weight. This research suggests metabolic health concerns for these common environmental contaminants, suggesting further need to assess molecular mechanisms and better characterize environmental concentrations for human health risk assessments.
We 💜 shrooms… as skincare! Studies show that mushrooms are rich in metabolites that can help fight free radicals, hydrating beta-glucans…
Whole Genome Association Study Of The Plasma Metabolome, 49% OFF
Metabolites, Free Full-Text
En Dag I Taget Get File - Colaboratory
Distinct signatures of gut microbiota and metabolites in different types of diabetes: a population-based cross-sectional study - eClinicalMedicine
Metabolomics and complementary techniques to investigate the plant phytochemical cosmos - Natural Product Reports (RSC Publishing) DOI:10.1039/D1NP00014D
PDF The Novel Isoflavone Derivatives Inhibit RANKL Induced
Metabolites, Free Full-Text
Metabolites, Free Full-Text
Evolution and regulation of microbial secondary metabolism
An integrated in vivo/in vitro framework to enhance cell-free biosynthesis with metabolically rewired yeast extracts
Metabolites, Free Full-Text
Metabolites, Free Full-Text
Dr. David Ludwig on X: How might a high-carb diet drive fat storage, increase hunger and slow metabolism? Our new study assessed calories in the blood available to fuel metabolism after eating.
